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Symbol
Name
ID

Cdk6
cyclin dependent kinase 6
MGI:1277162

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased thymocyte apoptosis

increased T cell apoptosis

decreased T cell proliferation

abnormal thymus morphology

thymus cortex atrophy

enlarged thymus

small thymus

thymus atrophy

thymus hypoplasia

decreased thymocyte number

decreased DN1 thymic pro-T cell number

decreased DN2 thymocyte number

decreased DN4 thymocyte number

increased thymocyte number

increased DN1 thymic pro-T cell number

increased DN3 thymocyte number

abnormal thymocyte activation

abnormal lymphopoiesis

abnormal T cell differentiation

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased single-positive T cell number

decreased leukocyte cell number

abnormal spleen morphology

abnormal spleen red pulp morphology

small spleen

spleen hypoplasia

Availability

Mouse Genotype

Cdk6^tm1.1Phin/Cdk6^tm1.1Phin

*

Cdk6^tm1Bbd/Cdk6^tm1Bbd

Cdk6^tm1Phin/Cdk6^tm1Phin

*

Cdk6^tm2.1Phin/Cdk6^tm2.1Phin

Cdk6^tm3.1Phin/Cdk6^tm3.1Phin

*

Cdk6^tm4.1Phin/Cdk6^tm4.1Phin

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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